Abstract: It is of great significance for the development of disciplines to sort out the development trends and research veins of subjects and reveal the evolution laws and characteristics of subjects in the field of disciplines. Based on life cycle theory and subject words, this paper analyzed the theme evolution in different life cycle stages of lung cancer targeting drug field from the perspective of network structure evolution characteristics and subject content evolution, and revealed the characteristics and rules of development in this field in an all-round and in-depth way. The experimental results in the field of lung cancer targeting drugs show that in the evolution of the Co-word network structure, the whole network varies with different stages; in the evolution of the subject content, the research topics mainly embody the four forms of "persistent", "new", "weakened" and "differentiated". Targeted drugs combined with traditional therapies are the main therapies for lung cancer. Therapeutic schemes and therapeutic effects will continue to be a research hotspot. Drug resistance and drug resistance mechanism of targeted drugs, application of new generation of targeted drugs and research status of immunotherapy will rise in the later stage, which will have potential for development. Research topics.

Key words: Subject area, Subject evolution, Network structure, Life cycle, Targeted drugs