Abstract: In order to establish a risk assessment and decision-making mechanism that adapts to the characteristics of different stages of the development and evolution of major public health emergencies, and play the collaborative and cooperative role of the participants and the decision support and driving role of information and knowledge, this paper constructs a dynamic and flexible risk assessment and decision-making model of major public health emergencies, which consists of four independent core levels : life cycle, risk assessment and decision-making, participants, information and knowledge, and the restricting factors and constraint conditions are the moderator variables. It provides a scientific and verifiable theoretical framework for the study of emergency management of major public health emergencies, and guides the risk assessment and decision-making practice under major public health emergencies.

Key words: Major public health emergencies, Risk assesment, Risk decision-making, Collaborative decision-making, Emergency management